Effect of Omega-3 Fatty Acid Intake on Circulating Biomarkörer of Atrial Fibrillation-Related Pathways in the PREDIMED-Plus Studie.

Denna analys använde 510 äldre spanska vuxna med metabolt syndrom från PREDIMED-Plus. Den undersökte om rapporterat vanemässigt omega-3-intag följde fem serummarkörer kopplade till förmaksflimmervägar under 5 år: NT-pro-BNP, högkänsligt troponin T, C-reaktivt protein, PICP och 3-nitrotyrosin. Intake was estimated with a validated 143-item food-frequency questionnaire, and markers were measured at baseline and after 3 and 5 years.

Median total omega-3 intake was 2.0 g/day. Total intake was not associated with any of the five biomarkers either at baseline or longitudinally. Marine omega-3 intake was associated cross-sectionally with 28.4% higher 3-nitrotyrosine in the highest versus lowest intake tertile, with a 95% confidence interval of 5.5% to 56.2% and a trend p-value of 0.014. That relationship was not present longitudinally. Moderate baseline non-marine omega-3 intake was associated with lower PICP after 5 years, but the association was isolated and non-linear.

This was an observational diet analysis, not a randomised omega-3 supplementation test. It measured biomarkers rather than atrial fibrillation itself. The overall result does not support a consistent relationship between usual total omega-3 intake and these proposed pathways.

Habitual total omega-3 intake was not associated with circulating biomarkers of atrial-fibrillation-related pathways.