The Relative Bioavailability of Lutein and Zeaxanthin in the Presence of Omega-3 Supplements and Their Effect on Oxidative Stress Levels in Humans: A Pilot Studie.

Denna randomiserade, icke-blindade, kontrollerade pilotstudie omfattade 16 vuxna, 10 män och sex kvinnor, med medelåldern 31,38 år. Efter en 7-dagars washoutperiod tog nio deltagare lutein plus zeaxantin i 12 mg/dag i 12 dagar. Sju tog samma karotenoidtillskott plus 900 mg/dag omega-3, som gav 540 mg EPA och 360 mg DHA. Both groups followed a low-carotenoid and omega-3 diet.

Serum lutein plus zeaxanthin increased in both groups. At day 19, concentrations were 2.98 µg/mL in the control group and 3.02 µg/mL in the omega-3 group. Conventional exposure measures, AUC from days 7 to 13 and 13 to 19, did not differ significantly. Incremental AUC suggested a higher mean post-washout response with omega-3, 4.36 versus 3.00 µg/day/mL, but this difference was also not statistically significant. Omega-3 co-supplementation did not significantly affect oxidative-stress biomarkers.

The study was short and measured absorption-related markers, not visual outcomes, macular degeneration or longevity. Its result does not demonstrate an added benefit from omega-3. The day-resolved incremental-AUC finding is exploratory in a sample of only 16 people.

Omega-3 co-supplementation did not show a consistent additional benefit for lutein and zeaxanthin bioavailability or oxidative-stress markers.