Combined Aerobic-Resistance Training and Taurine Supplementation Reduce Asprosin and Elevate Spexin in Men with Obesity: A 12-Week Supplement-Blinded, Randomized Controlled Trial.

I denna randomiserade, placebokontrollerade studie med blindning av tillskottet fördelades 44 män med fetma, definierad som BMI på minst 30 kg/m2, till fyra grupper om 11: placebokontroll, enbart taurin, träning plus placebo eller träning plus taurin. Taurin gavs i dosen 3 g/dag under 12 veckor. The exercise programme combined aerobic sessions at 60% heart-rate reserve with progressive resistance training at 60% of one-repetition maximum; training loads were re-estimated every four weeks. Outcomes included plasma asprosin, spexin and body-fat percentage, with body fat measured by bioelectrical impedance analysis. The abstract reports significant group-by-time interactions for all five outcomes, but portions of the numerical results are truncated. It does state that the combined exercise-plus-taurine group had reductions in BMI of 1.80 kg/m2 (p=0.002) and body-fat percentage of 4.90%, and that the combined intervention outperformed either component in the authors' analysis. This does not isolate a taurine effect from the full exercise-plus-supplement package. The reported endpoints are adipokines and body composition over 12 weeks, not clinical events or long-term health outcomes. The authors themselves describe the findings as preliminary and exploratory.

Combined aerobic-resistance training with taurine produced greater improvements in adipokine regulation and body composition than either modality alone, but the findings are preliminary and exploratory.