Studie
Efficacy och Säkerhet of Time-Restricted Eating i Adults With Type 1 Diabetes: A Randomiserad Kontrollerad Trial
In 32 adults with type 1 diabetes och overweight or obesity, six months of 8-hour time-restricted eating lowered HbA1c versus calorie restriction without increasing severe glycemic events, but did not clearly outperform control for weight loss.
Mary-Claire Runchey och colleagues randomiserad 32 adults with type 1 diabetes och overweight or obesity till 8-hour time-restricted eating, 25% daily calorie restriction, or no intervention for six months. The eating window ran från noon till 8 p.m. och did not require calorie counting. The primär endpoint was percentage change i body weight. Time-restricted eating produced a -2.19% change versus control, with a 95% confidence interval of -5.70 till -1.31. The abstract describes this contrast as not significant. The comparison with calorie restriction was -1.73% (95% CI -5.37 till 1.92). HbA1c fell more with time-restricted eating than with calorie restriction by -0.46 percentage points (95% CI -0.80 till -0.12). Total insulin dos och mean glucose did not differ significantly. No increase i diabetic ketoacidosis, severe hypoglycemia, or severe hyperglycemia appeared. This is a small, six-month dietary trial. It tests weight och glycemic outcomes, not lifespan or validated biological-age endpoints. The result supports short-term säkerhet och a possible HbA1c benefit, not a general longevity claim.
These findings suggest that TRE may be a safe approach for reducing HbA1c levels i T1D, although not more effektiv for weight loss compared with CR or a control group.
Small sample. Six-month duration. The studie was not powered for longevity outcomes. The time-restricted eating arm was compared with both calorie restriction och no intervention, so the independent effect of meal timing remains difficult till separate från changes i energy intake.
Citerad av
1 encyklopediartiklar refererar till denna studie.