Effect of resveratrol supplementation on SIRT1 expression and serum levels: a GRADE-assessed systematisk översikt and dose-response metaanalys

Det här är den viktigaste enskilda artikeln för alla som överväger att köpa resveratrol som kosttillskott mot åldrande. A 2025 GRADE-assessed systematisk översikt pooled 11 randomised controlled trials specifically measuring resveratrol's effect on SIRT1, the sirtuin the entire commercial narrative is built on. The pooled analysis found no significant effect on SIRT1 gene expression, no significant effect on protein expression, and no significant effect on serum SIRT1 levels. There was a signal that interventions shorter than 12 weeks showed a clearer effect, and a dose-response relationship existed, but not in a way that recovers the commercial claim. In plain terms: at the doses and durations most trials use, resveratrol does not activate SIRT1 in humans the way the mouse and yeast work predicted. Resveratrol may still do useful things at the metabolic and cardiovascular level. It is not, on this evidence, the sirtuin activator sold on supplement labels.

Pooled analysis of eleven RCTs found no significant effect of resveratrol supplementation on SIRT1 gene expression, protein expression, or serum levels.