Calcium-alpha-ketoglutarate supplement associated with 1.8-year lower biological age in 4,260-person cohort

Forskare under ledning av Brian K. Kennedy analyserade 4,260 personer som köpte salivbaserade DNA-epigenetiska tester mellan 2020 och 2025 och fyllde i detaljerade frågeformulär om livsstil och kosttillskott. Sjuttioen procent av kohorten uppgav att de använde kosttillskott. Using a proprietary 9-CpG epigenetic clock with a mean absolute error of 5.4 years, the team evaluated 84 commonly used supplements. A commercially available delayed-release calcium-alpha-ketoglutarate (dAKG) plus vitamin supplement, identified as Rejuvant, was associated with an average 1.8-year lower Age Residual (the difference between biological and chronological age). This association held after adjusting for age, sex, smoking, health status, and additional covariates. Deltagare who reported taking regular AKG (not the delayed-release formulation) showed a much smaller, statistically insignificant benefit. Among medications, antihistamine use showed a non-significant trend toward benefit, limited by sample size. The study is cross-sectional, meaning it cannot prove causation: people who take supplements may differ from non-users in unmeasured ways. The 9-CpG clock is proprietary and less validated than established clocks like GrimAge or DunedinPACE.

A delayed-release calcium-alpha-ketoglutarate plus vitamin supplement was associated with 1.8-year lower Age Residual in a cross-sectional cohort of 4,260 health enthusiasts.