Taurine supplementation shows promise for metabolic health and aging: comprehensive review

Researchers from Technische Universität Braunschweig and the University of São Paulo reviewed taurine's molecular functions and supplementation outcomes in metabolism, inflammation, and aging. Taurine is the most abundant free amino acid in many tissues and functions as a non-proteinogenic beta-amino acid. The review describes taurine's roles in antioxidant defense, anti-inflammatory signaling, calcium homeostasis, and mitochondrial function. Supplementation showed promising outcomes in human studies, particularly in precision nutrition and prevention of metabolic and age-related diseases. This review aligns with the 2023 Science study by Singh et al. that linked taurine deficiency to aging and showed 10 to 12 percent lifespan extension in supplemented mice. However, a 2025 NIH study concluded that taurine is unlikely to be a good aging biomarker because it did not longitudinally decline with age in human data. The current review does not resolve this discrepancy but adds mechanistic depth to taurine's multiple targets. No specific dose recommendations or effect sizes from individual human trials are provided in the review abstract.

Taurine supplementation has shown promising outcomes in human studies, with emerging relevance in precision nutrition and prevention of age-related diseases.