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Study

Blueprint Biomarkers platform

Bryan Johnson / Blueprint

PRIMARY Tier 4 2026
DesignPRIMARY
TierTier 4, Ingredient RCT (different dose)
Year2026
Journalblueprint.bryanjohnson.com
N3
Added to NO1GEVITYMay 19, 2026

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IngredientKlothoRecombinant protein and gene therapy←GoalGrimAge (DNAm GrimAge Epigenetic Clock)A second-generation epigenetic clock trained directly on mortali←StudyBlueprint Biomarkers platformblueprint.bryanjohnson.com 2026
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Cited by

26 encyclopedia entries reference this study.

MechanismAltered Intercellular CommunicationMechanismNAD+ DeclineMechanismSenescence ClearanceMechanismSirtuin ActivationMechanismTelomere AttritionBiomarkerApolipoprotein B (ApoB)BiomarkerBody Composition (Fat Mass, Lean Mass, Visceral Fat)BiomarkerCoronary Artery Calcium (CAC) ScoreBiomarkerDunedinPACE (Pace of Aging Clock)BiomarkerFrailty IndexBiomarkerGait SpeedBiomarkerGlycanAge (IgG Glycosylation Age)BiomarkerGrimAge (DNAm GrimAge Epigenetic Clock)BiomarkerGrip StrengthBiomarkerHorvath Clock (DNA Methylation Age)BiomarkerHeart Rate Variability (HRV)Biomarkerhs-CRP (High-Sensitivity C-Reactive Protein)BiomarkerInterleukin-6 (IL-6)BiomarkerNAD+ (Blood/Tissue Levels)BiomarkerPhenoAge (DNAm PhenoAge Epigenetic Clock)BiomarkerResting Heart Rate (RHR)BiomarkerTelomere Length (Leukocyte)BiomarkerTumor Necrosis Factor-alpha (TNF-alpha)Biomarker25-Hydroxyvitamin D (Vitamin D Status)BiomarkerVO2max (Maximal Oxygen Uptake)InterventionBlueprint Protocol