Study
Blueprint protocol page: sleep timing and hair regimen changes
PROTOCOL CHANGE: the page now sets a 2-hour minimum between the last meal and bed, with 4- and 6-hour tests; hair dosing is 7% topical minoxidil, 5 mg oral minoxidil, and a 302-diode cap.
The current Blueprint protocol page changes several practical details from the 12 August snapshot. The sleep section now says the last meal should be at least 2 hours before bed, with experiments at 4 and 6 hours. The older snapshot stated 4 hours as the target. The page still reports Johnson’s personal pattern of stopping food around noon and links a pre-bed resting heart rate of about 39 beats per minute with a good night’s sleep. The current hair section lists a 7% topical minoxidil solution at 1 mL each night, up from 5% in the prior snapshot. It lists oral minoxidil at 5 mg daily, up from 3.75 mg. The red-light device is now named the Blueprint 302 Laser Cap at 655 nm, replacing the generic red-light-cap wording. The daily routine still lists NR 450 mg or NMN 500 mg, metformin 500 mg in six-week cycles, and the other prescription items. These are protocol statements from one person, not comparative trials. The page now labels the material as historical personal protocol information and says some treatments are not FDA approved. The clearest update is the meal-timing revision; the page does not publish adherence data or a new outcome series for the change.
Try to have your last meal of the day at least two hours (experiment with 4 and 6 hours before) before bed and avoid large meals close to bedtime.
Niko Hems’ 13 August review says Johnson’s N=1 design cannot separate the effects of diet, exercise, sleep, and supplements, and that biomarker shifts do not prove longer healthy life. Eric Topol wrote that the 150-year Blueprint was “doomed to fail.” Neither piece supplies evidence for a meal-timing or hair-dose upgrade. URLs: https://www.years.co/en/blog/bryan-johnson-biomarkers-science-limits ; https://x.com/EricTopol/status/2088013677232521620
Cited by
3 encyclopedia entries reference this study.