Best urolithin A supplements to buy in 2026.
9 urolithin A products from 7 brands are tracked here, the smallest category of the four. Evidence grade A rests on one four-month RCT in 90 people that improved muscle strength by about 12 percent and missed its own registered primary endpoint. A confirmatory trial funded by the ingredient's maker completes in late 2027. Prices per day at trial dose range from under $2 to over $4.
Top picks: 9 urolithin A products from 7 brands, ranked.
Sorted by overall score. Trial dose for urolithin A is 1,000 mg per day, with a published range of 500 mg to 1,000 mg. Cost per day at trial dose is what it costs to reproduce the published dose, not the sticker price of a bottle. What is RxD-$?
Timeline Nutrition Mitopure® Softgel
ProHealth Longevity Full Spectrum Urolithin A - 60 capsules
Perpetua Life Urolithin-A Liposomal 1,000mg
| # | Product | Composite | Dose | Cost at trial dose | 3rd-party tested | Public lab certificate |
|---|---|---|---|---|---|---|
| 1 | Timeline Nutrition Mitopure® Softgel | 8.6 | 50% | $4.33/day | Yes | No |
| 2 | ProHealth Longevity Full Spectrum Urolithin A - 60 capsules | 8.6 | 50% | $3.73/day | Yes | Yes |
| 3 | Perpetua Life Urolithin-A Liposomal 1,000mg | 8.4 | 100% | $1.97/day | Yes | No |
| 4 | Timeline Nutrition Mitopure® Powder | 8.2 | 100% | $4.64/day | Yes | No |
| 5 | Timeline Nutrition Timeline Mitopure Gummies (Urolithin A, Strawberry) | 8.1 | 50% | $8.33/day | Yes | No |
Why these?
One formula, applied to all 307 products on the site. No brand pays to be here.
The overall score is a weighted sum of six pillars:
- 0.50 Dose and evidence. How close the label serving sits to the dose used in published human trials, weighted by how good that evidence is.
- 0.20 Transparency. Public batch-specific Certificate of Analysis, named lab, stated actives.
- 0.10 Value. Cost per day at trial dose, compared against the rest of the category.
- 0.10 Formulation. Form, bioavailability, and whether the delivery matches the trial material.
- 0.05 Safety. Documented adverse events, contamination history, interaction load.
- 0.05 Community. Verified consumer reports, weighted down hard because reviews are noisy.
Dose carries half the weight because a well-tested product at a quarter of the trial dose is still a product that cannot reproduce the trial. Read the full methodology for the arithmetic and the sensitivity analysis.
What the evidence shows.
Urolithin A carries evidence grade A on this site. Every study below is linked to its source. Nothing here is summarised from a secondary write-up.
Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health
Registered as NCT03464500. 90 middle-aged, overweight, inactive adults were randomised to 500 mg of urolithin A, 1,000 mg, or placebo for four months. Muscle strength improved roughly 12 percent. Peak VO2 and six-minute walk distance improved. Plasma acylcarnitines and C-reactive protein fell. The registered primary endpoint, change in cycle-ergometer power output at day 120, was not significantly improved, so the strength and endurance findings that drive the marketing were secondary. Funded and co-authored by Amazentis, which sells Mitopure.
ATLAS 2: a confirmatory trial of urolithin A on muscle strength and performance
A registration, not a result. 120 healthy adults aged 40 to 65 with BMI 25 to 34.9 take placebo, 500 mg, or 1,000 mg of Mitopure daily for six months. The primary endpoint is change in maximum isokinetic knee flexion strength measured by Biodex dynamometry, a direct strength measure rather than the power output the 2022 trial missed on. Sponsored by Amazentis, which sells the ingredient. Estimated completion October 2027. Until it reports, this category rests on one four-month trial.
How to choose.
- Buy direct urolithin A, never a "precursor". Pomegranate extract only becomes urolithin A if you carry the right gut bacteria, and roughly 40 percent of people do. A pomegranate or ellagitannin product is a bet on your microbiome. Direct urolithin A skips the step, which is the entire point of the supplement.
- Target 500 mg to 1,000 mg per day. The 2022 trial dosed at 500 mg and 1,000 mg for four months and ATLAS 2 is testing the same two doses. Both sit inside the range with human data behind them. No published trial shows 1,000 mg beating 500 mg, so paying double for the higher dose buys no evidence.
- Check the CoA for urolithin A content, not extract weight. This is a synthesised molecule with a small number of suppliers. A dated batch-specific Certificate of Analysis from an independent lab is the only way to confirm what is in the capsule. What a CoA is.
- Regulatory status is the cleanest of the four. Urolithin A is an authorised novel food in the EU under Regulation 2021/85, authorised in the UK, and holds FDA GRAS status in the US. Shipping is straightforward everywhere the other three have friction. See the regulatory tracker.
Common questions
How much urolithin A should I take?
500 mg to 1,000 mg per day. Those are the two doses used in the 2022 trial by Singh A and colleagues, where muscle strength rose about 12 percent, and the same two doses ATLAS 2 is testing over six months.
Is pomegranate extract the same as urolithin A?
No. Pomegranate ellagitannins convert to urolithin A only in people with the right gut bacteria, roughly 40 percent of the population. Direct urolithin A works regardless of your microbiome.
Did the urolithin A trial actually work?
Partly. Muscle strength rose about 12 percent and endurance measures improved in 90 adults over four months, but the registered primary endpoint, cycle-ergometer power output at day 120, was not significantly improved. The strength result was a secondary endpoint.
Is Mitopure the only real urolithin A?
Mitopure is Amazentis's branded urolithin A and it is the material used in the published trials. Other brands sell urolithin A that is not Mitopure. Judge those on the Certificate of Analysis, which is why third-party testing is weighted in the score.
Is urolithin A approved in the EU?
Yes. It is an authorised novel food in the EU under Regulation 2021/85 and holds FDA GRAS status in the US, which makes it the least restricted of the four molecules covered in these guides.
When will there be better evidence?
ATLAS 2 (NCT07231783) gives 120 healthy adults aged 40 to 65 placebo, 500 mg, or 1,000 mg for six months, with maximum isokinetic knee flexion strength as the primary endpoint. Estimated completion is October 2027. Until then the category rests on one four-month trial funded by the company selling the ingredient.
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Questions or a correction on any number on this page: [email protected].