Nestle-Led Clinical Studie: NR and NMN Promote Metabolic Health in Unexpected Ways

A Nestle Health Science-led clinical study found that 14-day supplementation of nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) combined produced changes in metabolic health markers that were not previously described. This is notable because most NAD+ precursor studies have focused on raising blood NAD+ levels or measuring physical performance endpoints. The metabolic pathway changes suggest NAD+ boosters may have effects beyond simple NAD+ elevation. The short 14-day duration limits conclusions about sustained effects. The study is industry-funded (Nestle Health Science), which is a conflict of interest to consider when evaluating the claims. Results were published on the Nestle Health Science website rather than in a peer-reviewed journal at time of writing.

First-time evidence that 14-day supplementation of NR and NMN could promote health in unexpected ways.